Driving the Byway
- The byway begins at the North Carolina/Tennessee border. Travel northwest on US-25 to Del Rio.
- In Del Rio, continue northwest through the town of Newport.
- Pass through Newport and continue on US-25 E through the town of White Pine.
- Continue heading northwest on US-25 E, and pass through the town of Cumberland Gap.
- The byway ends at the Kentucky/Tennessee border. Here, you can travel through Kentucky on the Wilderness Road Heritage Highway.