Driving the Byway
- Begin at at the Indiana-Illinois border on US 50/US150.
- Continue east through Shoals, IN.
- From US 150/50 in Shoals, IN, continue northeast on US 50 through Lawrenceburg, IN to the Indiana-Ohio border.
- From US 50/US150 at Shoals, IN, continue southeast on US 150 into New Albany, IN.
- Continue east on local roads.
- End at the Falls of the Ohio State Park in Clarksville, IN. (201 West Riverside Dr.)