| AASHTO | American Association of State Highway and Transportation Officials |
| ACM | Asset Conditions Reporting Module |
| ADA | Americans with Disabilities Act of 1990 |
| ADT | Average daily traffic |
| APTA | American Public Transportation Association |
| ATS | Alternative transportation (transit) system |
| BAC | Blood alcohol concentration |
| BCR | Benefit/cost ratio |
| BLM | Bureau of Land Management |
| BNIP | Bridge Needs and Investment Process |
| BTS | Bureau of Transportation Statistics |
| C&P | Conditions and Performance |
| CMAQ | Congestion Mitigation and Air Quality Improvement Program |
| CMV | Commercial motor vehicle |
| CNG | Compressed natural gas |
| Combo | Combination truck |
| COP | Certificate of participation |
| CPI | Consumer Price Index |
| CR | Compliance Review |
| CTAA | Community Transportation Association of America |
| DHS | U.S. Department of Homeland Security |
| DMS | Dynamic message sign(s) |
| DoD | U.S. Department of Defense |
| DOI | U.S. Department of the Interior |
| DOT | U.S. Department of Transportation |
| DVMT | Daily vehicle miles traveled |
| FARS | Fatality Analysis Reporting System |
| FHMR | Federal Hazardous Materials Regulation |
| FHWA | Federal Highway Administration |
| FLHP | Federal Lands Highway Program |
| FLMA | Federal Lands Management Agency |
| FMCSA | Federal Motor Carrier Safety Administration |
| FMCSR | Federal Motor Carrier Safety Regulation |
| FRA | Federal Railroad Administration |
| FTA | Federal Transit Administration |
| FY | Fiscal year |
| GAN | Grant Anticipation Note |
| GAO | Government Accountability Office |
| GARVEE | Grant Anticipation Revenue Vehicle |
| GDP | Gross domestic product |
| GPS | Global positioning system |
| HBRRP | Highway Bridge Replacement and Rehabilitation Program |
| HERS | Highway Economic Requirements System |
| HFCS | Highway Functional Classification System |
| HTF | Highway Trust Fund |
| HOV | High occupancy vehicle |
| HPMS | Highway Performance Monitoring System |
| HPMS-AP | Highway Performance Monitoring System Analytical Process |
| HSIP | Highway safety improvement program |
| HSPD | Homeland Security Presidential Directive |
| IHSDM | Interactive Highway Safety Design Model |
| IRI | International Roughness Index |
| ISAC | Information Sharing and Analysis Centers |
| ISTEA | Intermodal Surface Transportation Efficiency Act of 1991 |
| ITS | Intelligent Transportation System |
| LNG | Liquefied natural gas |
| LPG | Liquefied petroleum gas |
| LTAP | Local Technical Assistance Program |
| LUST | Leaking Underground Storage Tank |
| MMUCC | Model Minimum Uniform Crash Criteria |
| MPO | Metropolitan planning organization |
| MSA | Metropolitan statistical area |
| MTA | Mass Transit Account, New York Metropolitan Transportation Authority |
| NAFTA | North American Free Trade Agreement |
| NBI | National Bridge Inventory |
| NBIAS | National Bridge Investment Analysis System |
| NBIP | National Bridge Inspection Program |
| NBIS | National Bridge Inspection Standards |
| NCHRP | National Cooperative Highway Research Program |
| NHS | National Highway System |
| NHTS | National Household Travel Survey |
| NHTSA | National Highway Traffic Safety Administration |
| NPS | National Park Service |
| NPTS | Nationwide Personal Transportation Survey |
| NTD | National Transit Database |
| NTI | National Transit Institute |
| OIG | Office of Inspector General (DOT) |
| PMT | Passenger miles traveled |
| POE | Port of entry |
| PPP | Public-Private Partnerships |
| PRISM | Performance and Registration Information Systems Management |
| PSR | Present Serviceability Rating |
| PT-ISAC | Public Transportation-Information Sharing and Analysis Centers |
| PV | Passenger vehicle |
| ROR | Run off the road |
| SAFETEA | Safe, Accountable, Flexible, and Efficient Transportation Equity Act |
| SBRP | Special Bridge Replacement Program |
| SDDCTEA | Surface Deployment and Distribution Command Transportation Engineering Agency |
| SEPTA | Southeastern Pennsylvania Transit Authority |
| SIB | State Infrastructure Bank |
| SQC | Synthesis, Quantity, and Condition |
| ST-ISAC | Surface Transportation-Information Sharing and Analysis Centers |
| STP | Surface Transportation Program |
| STRAHNET | Strategic Highway Network |
| SU | Single-unit truck |
| SUV | Sport utility vehicle |
| TEA-21 | Transportation Equity Act for the 21st Century |
| TEAM | Transit Electronic Award and Management |
| TERM | Transit Economic Requirements Model |
| TIFIA | Transportation Infrastructure and Finance Innovation Act of 1998 |
| TMC | Transportation management center |
| TPMS | Transit Performance Monitoring System |
| TSI | Transportation Safety Institute |
| TTI | Texas Transportation Institute |
| TVMT | Truck vehicle miles traveled |
| USDA | U.S. Department of Agriculture |
| USFS | U.S. Forest Service |
| USFWS | U.S. Fish and Wildlife Service |
| V/SF | Volume to service flow |
| VMT | Vehicle miles traveled |
| VRM | Vehicle revenue mile |
