Driving the Byway
- Begin at the Tennessee/Kentucky border on US25E southeast of Middlesboro, KY.
- Drive northeast on US25E.
- Follow US25E for 30 miles through Middlesboro and Pineville until the junction with KY229 just north of Barbourville.
- Drive north on KY229 for 21 miles to the junction with US25 in London.
- Go north on US25 through Laurel and Rockcastle counties until reaching Berea in Madison County.
- The byway ends at the intersection of US25 and Boone St. in Berea, KY.